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Reginald Sheffield was born Matthew Reginald Sheffield Cassan in the St. George's, Hanover Square district of London, to Matthew Sheffield Cassan and Alice Mary Field. He had a brother, Edward Sheffield Cassan, and a sister, Flora Kathleen Sheffield Cassan, who became an actress known as Flora Sheffield.
His father was born in Ireland and his mother in England. They were married in London in 1892. Matthew died when Reginald was nine. In 1913 Reginald (billed as Eric Desmond) appeared in David Copperfield. In 1914, Alice Sheffield and her children emigrated to the United States, where they lived in Queens, New York. Reginald acted on the stage and in films. While his sister Flora was an actress, brother Edward worked as an accountant in a bank and later became a theatrical agent.
Sheffield's Broadway performances credited as Reggie Sheffield include Evidence (1914), in which his mother also appeared, The Merry Wives of Windsor (1916), If (1917), The Betrothal (1918), and Helena's Boys (1924). His performances credited as Reginald Sheffield include Youth (1920), The Way Things Happen (1924), Hay Fever (1925), Slaves All (1926), Soldiers and Women (1929), and Dear Old England (1930).
Reginald Sheffield was married in 1927 to Louise Van Loon (21 January 1905 – 14 April 1987), a New York-born Vassar College graduate with a liberal arts education. The couple had three children: Mary Alice Sheffield Cassan (born 1928), Jon Matthew Sheffield Cassan (11 April 1931 – 15 October 2010) (aka actor Johnny Sheffield), and William Hart Sheffield Cassan (15 July 1935 – 12 December 2010) (actor Billy Sheffield).
As film production became more and more located in Southern California, Sheffield and his wife travelled back and forth between New York City and Los Angeles. After several years they moved permanently to the West Coast.
Being a trained stage actor, Sheffield easily made the transition from silent films to talkies. He was a working actor who became memorable in numerous character and supporting roles and appeared with some of the greatest film stars of the day, including Constance Bennett, William Powell, George Arliss, Loretta Young, Gary Cooper, Errol Flynn, Rosalind Russell, Cary Grant and Joan Fontaine.
In 1954, he began starring as Professor Mayberry in the television series Rocky Jones, Space Ranger. And after his son, Johnny Sheffield [of first the Tarzan then the Bomba films series], appeared in his last jungle film in 1955, Reginald created, produced and directed a pilot for a television series, Bantu, the Zebra Boy, but a sponsor was not found and the show was never produced as a weekly series.
Sheffield acted in both versions, 1938 and 1958, of Cecil B. DeMille's The Buccaneer, the latter being his last screen appearance.
Reginald Sheffield died 8 December 1957 at his home in Pacific Palisades, California, aged 56.
1958
as Hotel Desk Clerk (uncredited)
1957
as Julius Caesar
1956
as Edward Lancaster
1956
1954
as Lord Constable (uncredited)
1954
1953
as Mr. Woburn, English tourist
1953
as Coudray's Stage Manager
1952
as Inspector Blaney
1949
as English Charlie / Watkins the Butler
1949
as Auctioneer (uncredited)
1948
as Superintendent
1948
1948
as Solicitor (uncredited)
1947
as Commanding Officer (uncredited)
1947
as Travel Agent (uncredited)
1946
as Harry, Reporter
1946
as Charles Dickens (uncredited)
1946
as Hotel Clerk
1945
as Captain of the King's Guard (uncredited)
1945
as McQuarrie (uncredited)
1945
as Art Expert at Party
1944
as Purser (uncredited)
1943
as Reuter's English Reporter
1943
as Miller - Wilson's Butler (uncredited)
1942
as Victor
1942
as Doc
1941
as Reggie Wetherby
1941
as Professor Jones (uncredited)
1940
as Steward (Uncredited)
1940
as Defense Attorney
1940
as Thurston
1940
as Judge Tyler
1939
as Rudyard Kipling - Journalist
1938
as Dr. Richardson
1938
as Ship's Surgeon
1936
as Patient (uncredited)
1935
as Billy Grimes
1935
as Lord Michael
1935
as Richelieu's Outrider
1934
as Flight Cmdr. King (uncredited)
1934
as Tommy
1934
as Cyril Dunsford
1931
as John Durrant
1930
as Bob Pillin
1930
as Lieutenant Cardew
1928
as Will Dorsey
1926
as Peter de Peyster
1925
as Alexis Thompson
1924
as Bert Stafford
1919
as Sammy Wilson
1919
as Ogden Pett
1914
as Tommy (as Eric Desmond)
1913
as David Copperfield as a Child (as Eric Desmond)