Kernohan began her career in 1988 when she appeared in the low-budget slasher film Fatal Pulse. She appeared in several other films during 1988 including Roger Corman remake Not of This Earth, the post apocalyptic action film She-Wolves of the Wasteland and the film in which she is best known for, Critters 2: The Main Course, where she plays "Lee", the bounty hunter. The same year she appeared in the documentary The Decline of the Western Civilization Part II: The Metal Years. In 1989, she appeared in the action film Tango & Cash and the Playboy documentary Playboy: Sexy Lingerie. In 1990 she starred in Angel III: The Final Chapter, and her final film came in 1991 when she played herself in the direct-to-video film Scream Queen Hot Tub Party.
In 1993, Kernohan died in hospital of injuries following a car accident.
1991
as Roxanne Kernohan
1989
as Dressing Room Girl
1989
as Model
1988
as White Hooker
1988
as Meda
1988
as Lead Hooker
1988
as Lee
1988
as Ann
1987