Ruben Nikolayevich Simonov (Russian: Рубен Николаевич Симонов (2 April 1899, Moscow, Russian Empire – 5 December 1968, Moscow, Soviet Union) was a Soviet and Russian actor, theater director and pedagogue, as well as a People's Artist of the USSR (1946).
Simonov was born in a family of Russian Armenians. Graduating from the Moscow State University, he then became an actor, starting his career at the Armenian drama studio in the Armenian House of Culture. In 1939 he became director of the Vakhtangov Theatre. He also led the Armenian and Uzbek theaters of Moscow.