Tucci made her Broadway debut in 1963, in The Milk Train Doesn't Stop Here Anymore. She has fourteen Broadway credits. Principal roles include Rose Delle Rose opposite Maureen Stapleton in the 1966 production of The Rose Tattoo by Tennessee Williams. In 1967, she starred as Alexandra Giddens in a revival of The Little Foxes by Lillian Hellman, with Anne Bancroft as her mother. In 1969, she was a replacement for Jane Alexander in The Great White Hope. In 1988, she starred in a revival of The Night of the Iguana as Hannah Jelkes. In 2009, she appeared in the production of Mary Stuart as Hanna.
Tucci began appearing in film in 1969. Her first credits were in Robert Frank's Me and My Brother and a CBS Playhouse production titled Shadow Game. She played Lisa in Sidney Lumet's 1983 film Daniel. In Gus Van Sant's 1995 film To Die For she portrayed Angela Maretto.
She was nominated for a Tony Award for Best Featured Actress in a Play in 1967 for her performance in The Rose Tattoo. She played Koula in the 2015 mini-series The Slap. She also won an OBIE award for her performance as Phaedo in "Talk" by Carl Hancock Rux at the Joseph Papp Public Theater.
2025
as Marcella Hazan (voice)
2021
as Dr. Krystal
2015
as Koula
2006
as Self
1999
as Civita Tanzi
1999
as Anne Briggs
1996
as Mrs. Paterno
1995
as Angela Maretto
1995
as Monika's Mother
1990
as Helen Brolin
1989
as Self
1988
1986
as Dee Dee
1983
as Lise Lewin
1983
as Alexandra
1976
as Lea Gianni
1975
as Ruth Atkins
1973
as The Psychiatrist
1972
as Marie Mills
1971
as Ruth Atkins
1969
1969
1966