The Substance
2024A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Acted in
Demi Moore
as Elisabeth
Margaret Qualley
as Sue
Dennis Quaid
as Harvey
Edward Hamilton-Clark
as Fred
Gore Abrams
as Oliver
Oscar Lesage
as Troy
Christian Erickson
as Man at Diner
Robin Greer
as Male Nurse
Tom Morton
as Doctor
Hugo Diego Garcia
as Diego - Boyfriend
Daniel Knight
as Casting Director
Jonathon Carley
as Assistant Casting Director
Jiselle Henderkott
as Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
as TV Host
Vincent Colombe
as Man in Suit #1 - Harvey's Office
Billy Bentley
as Man in Suit #2
Lennard Ridsdale
as Man in Suit #3
Jordan Ford Silver
as Assistant Director - Pump It Up Show
Oscar Salem
as 2nd Assistant Director - Pump It Up Show
Viviane Bossina
as Sue's Assistant
Matthew Luret
as Floor Runner
Jana Bittnerová
as Maria
Olivier Raynal
as Alan - 2nd Agent
Tiffany Hofstetter
as Stylist
Nicolas Royer
as Guy in the Elevator
Nathan Rippy
as Assistant Director - New Year's Eve Show
Manon Arizmendi
as Little Girl - New Year's Eve Show
Virginie Kotlinski
as Mother - New Year's Eve Show
Brett Gillen
as Director of Photography - New Year's Eve Show
Charlotte Marquardt
as Screaming Woman
Léa Hengl
as Screaming Woman
Gaëlle Raymond
as Screaming Woman
Claire Lemaire
as Screaming Woman
Lila Boughoufala
as Screaming Woman
Aurélien Lorgnier
as Screaming Man
Ivan Sellier
as Screaming Man
Philip Schurer
as Screaming Man
Christian Bourmier
as Shareholder
Martin Graham
as Shareholder
Christian Bordeleau
as Shareholder
Patrick Hamel
as Shareholder
Didier D'Hondt
as Shareholder
Jacques-Yves Dorges
as Shareholder
Jean-Claude Matthey
as Shareholder
Olivier Jarcin
as Shareholder
Jean-Luc Magneron
as Shareholder
Charlotte Murray
as Allison - Diner Waitress
Aaron Kahn
as Greeting Person
Gabriela Arnon
as Greeting Person
Nancy Josephson Lahoussine
as Greeting Person
Andrew Eldridge
as Greeting Person
Denise Powers
as Greeting Person
Bryan Jones
as Greeting Person
Adam Carage
as Happy Birthday Person
Maria McClurg
as Happy Birthday Person
Andrew Desmond
as Happy Birthday Person
Rebecca Lafont
as Happy Birthday Person
Laura Puech
as Isabella
Ryan Chidester
as Stagehand
Céline Vogt
as Elisabeth (Young) - Walk of Fame
Yannick Guérin
as Clumsy Burger Guy - Walk of Fame
Jean Miel
as Worker Walk of Fame
Paul Descoings
as Worker Walk of Fame
Benoit Lévêque
as Worker Walk of Fame
Arthur Molinet
as Cocktail Bartender
Manon Sachot
as Cocktail Lounge Couple
Bastien Jorelle
as Cocktail Lounge Couple
Kelly Hoarau
as Female Assistant - Towel
Michel Juskiewicz
as George - Harvey's Friend
Louise Greggory
as Restaurant Waitress
Christophe Sartirano
as Guy Looking at Sue
Florent Torres
as Guy Looking at Sue
Romain Caldeira
as Billboard Technician
Barthelemy Thomas
as Billboard Technician
Axel Baille
as Photographer
Ashley Lambert
as Additional Voices (voice)
Ranjani Brow
as Additional Voices (voice)
Chase Fein
as Additional Voices (voice)
Shane Sweet
as Additional Voices (voice)
William Calvert
as Additional Voices (voice)
Michael Corbett
as Additional Voices (voice)
Stephen Apostolina
as Additional Voices (voice)
Yann Bean
as The Substance (voice)
Audrey Alcide
as Pump It Up Show Dancer
Jonathan Jenvrin
as Pump It Up Show Dancer
Mimi Maury
as Pump It Up Show Dancer
Amelye Solange
as Pump It Up Show Dancer
Kévin Table
as Pump It Up Show Dancer
Laura Boera
as Sparkle Your Life Show Dancer
Cissy Duc
as Sparkle Your Life Show Dancer
Sophie Mercier
as Sparkle Your Life Show Dancer
Marie Valton
as Sparkle Your Life Show Dancer
Katrina Budzynski
as New Year's Eve Show Dancer
Alicia Maury
as New Year's Eve Show Dancer
Megane Adamik
as New Year's Eve Show Dancer
Annalisa Pagnotta
as New Year's Eve Show Dancer
Maelle Dantigny
as New Year's Eve Show Dancer
Aleksandra Fontaine Kedzierska
as New Year's Eve Show Dancer
Pauline Sagetat
as New Year's Eve Show Dancer
Agustina Fitzsimons
as New Year's Eve Show Dancer
Elena Shcheglova
as New Year's Eve Show Dancer
Eve Marchant
as New Year's Eve Show Dancer
Lola Donati
as New Year's Eve Show Dancer
Kate Matthews
as New Year's Eve Show Dancer
Ophélie Jonard
as New Year's Eve Show Dancer
Pauline Richard
as New Year's Eve Show Dancer
Laureen Cappelliez
as New Year's Eve Show Dancer
Daria Panchenko
as New Year's Eve Show Dancer
Delphine Beaulieu
as New Year's Eve Show Dancer
Victoria Brun
as New Year's Eve Show Dancer
Cara Chapman
as New Year's Eve Show Dancer
Katharine Matthews
as New Year's Eve Show Dancer
Alexandra Faget
as New Year's Eve Show Dancer
Clémence Juville
as New Year's Eve Show Dancer
Margot L'Entete
as New Year's Eve Show Dancer
Hillary Sukhonos
as New Year's Eve Show Dancer
Matthew Géczy
as Bob Haswell (uncredited)
Namory Bakayoko
as Silhouette (uncredited)
Gregory Defleur
as Happy Birthday Person (uncredited)
Coralie Fargeat
as Elizabeth's Arm During Injection / Monstro Elisasue (some shots) (uncredited)