The major sub-plot circles around the youngest Griffin, Stewie, who has a near-death experience at a pool when a lifeguard chair falls on him, but he survives. After having a vision of being in Hell, he decides to change his ways, but this doesn't last long. While watching television, he and Brian spot a man that looks like Stewie. Brian is convinced that he is Stewie's real father, until Stewie learns that the man is actually himself as an adult, taking a vacation from his own time period. Baby Stewie visits thirty years later to discover that his adult self, going by the name Stu, is a single blue-collar middle-aged virgin working at a Circuit City-type store. Meanwhile, Peter and Lois are trying to teach their two older kids, Meg and Chris, to date. In the future, Chris, who hasn't changed much, is working as a cop and is married to a foul-mouthed hustler named Vanessa. Meg is now called Ron, since she had a sex-change after college.
as Stewie Griffin / Various Characters (voice)
as Lois Griffin / Various Characters (voice)
as Chris Griffin / Various Characters (voice)
as Meg Griffin / Various Characters (voice)
as Joe Swanson (voice)
as Diane Simmons (voice)
as Drew Barrymore (voice)
as Cleveland Brown / John Herbert (voice)
as Katie Couric / Baby-Expecting Woman / Britney Spears (voice)
as Elmer Fudd (voice)
as Ollie Williams /Various Characters (voice)
as Horace / Additional Voices (voice)
as Various Characters (voice)
as Promo Announcer (voice)
as Clerk (voice)
as Ray Charles / Various Characters (voice)
as Various Characters (voice)
as Randy Newman / James Lipton (voice)
as Various Characters (voice)
as Casper (voice)
as Meg 'Ron' Griffin (voice)
as Mayor Adam West (voice)
as Various Characters (voice)
as Odo (voice)
as Meg Griffin (singing voice) / Various Characters (voice)
as Various Characters (voice)
as Kelly Taylor (voice)
as Lion-O (voice)
as Cheetara (voice)
as Brandon Walsh (voice)
as The Stork (voice)
as Various Characters (voice)
as Al Harrington (voice)
as Donna Martin (voice)
as Joy Behar (voice)
as Various Characters (voice)
as Various Characters (voice)
as Indian (voice)
as Jesus Christ (voice)
as Various Characters (voice)
as Various Characters (voice)