Eight years after the third film, the OSS has become the world's top spy agency, while the Spy Kids department has since become defunct. A retired spy Marissa is thrown back into the action along with her stepchildren when a maniacal Timekeeper attempts to take over the world. In order to save the world, Rebecca and Cecil must team up with their hated stepmother. Carmen and Juni have since also grown up and will provide gadgets to them.
as Marissa Wilson
as Wilbur Wilson
as Rebecca Wilson
as Cecil Wilson
as Danger D'Amo / Tick Tock / Time Keeper
as Carmen Cortez
as Juni Cortez
as Uncle Machete
as Spy Baby
as Spy Baby
as Voice of Argonaut
as Argonaut
as Young Danger
as News Anchor
as Head Scientist
as Editor / Cameraman
as Wilbur's Boss
as OSS Agent #1
as OSS Agent #2
as Female OSS Agent
as Henchman in Van
as Agent Fine
as Gregorio Cortez (uncredited)