Holmes, retired to Sussex, is drawn into a last case when his arch enemy Moriarty arranges with an American gang to kill one John Douglas, a country gentleman with a mysterious past. Holmes' methods baffle Watson and Lestrade, but his results astonish them. In a long flashback, the victim's wife tells the story of the sinister Vermissa Valley.
as Sherlock Holmes
as Prof. Moriarty
as John Douglas
as Dr. John Watson
as Insp. Lestrade
as Mrs. Hudson
as Cecil Barker
as Ettie Douglas
as Ted Balding
as Boss McGinty
as Col. Sebastian Moran
as Ames
as Captain Marvin
as Jacob Shafter