After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
as Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)
as Marge Simpson / Selma Bouvier / Patty Bouvier (voice)
as Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)
as Lisa Simpson (voice)
as Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)
as Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)
as Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice)
as Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)
as Russ Cargill (voice)
as Man / EPA Driver (voice)
as Edna Krabappel (voice)
as Martin Prince (voice)
as Helen Lovejoy (voice)
as TV Dad (voice)
as Billie Joe Armstrong (voice)
as Mike Dirnt (voice)
as Tre Cool (voice)
as Fat Tony (voice)
as Tom Hanks (voice)