A mysterious creature destroys 70% of the moon. The creature then warns that if he is not destroyed by March of next year, Earth will be next. The creature also demands that he becomes the homeroom teacher for 3rd grade E class at Kunugigaoka Junior High School. The government is powerless to say no. The creature then becomes the homeroom teacher of 3rd grade E class which consists of failed students including Nagisa Shiota. The creature is called Teacher Koro. Meanwhile, the government requests that the students try to kill Teacher Koro even though he possesses super powers. The government offers a 10 billion yen reward for whomever successfully kills him. The students are confused by the situation, but decide to kill Teacher Koro. When their class begins with Teacher Koro, the students finds themselves having a good time with their new teacher.
as Koro Sensei (voice)
as Nagisa Shiota
as Karuma Akabane
as Kaede Kayano
as Rio Nakamura
as Yukiko Kanzaki
as Manami Okuda
as Tadaomi Karasuma
as Taiga Okajima
as Ryunosuke Chiba
as Hinata Okano
as Yuuma Isogai
as Irina Jelavic
as Kirara Hazama
as Manami Okuda
as Megu Kataoka
as Ryoma Terasaka
as Muramatsu Takuya
as Hinano Kurahashi
as Taisei Yoshida
as Toka Yada
as Hayami Rinka
as Maehara Hiroto
as Masayoshi Kimura
as Sosuke Sugaya
as Kotaro Takebayashi
as Yuzuki Fuwa
as Tomohito Sugino
as Mimura Koki
as Sumire Hara
as Ritsu
as Itona
as Ayaka Saitou
as Koki Mimura
as Akira Takaoka
as Aguri Yukimura
as Shiro
as Toka Yada
as Goki Onaga