The film is divided into two episodes: "The Acquaintance" (based on the 1892 short story "The Adventure of the Speckled Band") and "Bloody Inscription" (based on the 1887 novel A Study in Scarlet).
as Sherlock Holmes
as Dr. Watson
as Mrs. Hudson
as Helen Stoner / Julia Stoner
as Stamford
as Dr. Roylott
as Inspector Lestrade
as Inspector Gregson
as Jefferson Hope
as Joseph Stangerson
as Enoch Drebber
as Dr. Roylott / Inspector Lestrade (Voice)