When he was 12 years old, Bill Cody, later knew as Buffalo Bill, is rider for "pony express" carrying the mail through the wilds of America. It becomes later caravans guide. When driving one of them meets Luisa, the niece of a priest who tried to evangelize the savage tribes accompanied by a converted Indian. It is a dangerous time because, before the advancing white man, the Sioux tribes are buying weapons from unscrupulous dealers...
as Buffalo Bill Cody
as Wild Bill Hickok
as Calamity Jane
as Pastor Norman Lieberman
as Ethel Lieberman
as Ted
as Luisa
as Guillermo
as Colonel Carr
as Dittle
as St. James
as Agnes St. James
as Frank North
as Steve
as Red Cloud
as Douglas
as Utter
as Charlie
as Señorita Mortimer
as Chica de saloon
as Russell
as Majors
as Waddell
as Mortimer
as Padre de Bill
as Madre de Bill
as Hija de Steve